Due to Omicron's thankfully lesser virulence, I worry that people are overly complacent about the next potential variant. Here's one argument that the relevant selection pressures are no guarantee of continued evolution in our favor.
Antigenic evolution will lead to new SARS-CoV-2 variants with unpredictable severity - Nature Reviews Microbiology
The comparatively milder infections with the Omicron variant and higher levels of population immunity have raised hopes for a weakening of the pandemic. We argue that the lower severity of Omicron is a coincidence and that ongoing rapid antigenic evolution is likely to produce new variants that may escape immunity and be more severe.
nature.com